Premium
Age‐Related Changes in Memory and Their Pharmacologic Modulation
Author(s) -
AGUT JULIÁN,
ORTIZ JOSÉ A.
Publication year - 1991
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1991.tb00237.x
Subject(s) - choline , stimulus (psychology) , noxious stimulus , audiology , medicine , psychology , developmental psychology , cognitive psychology , receptor , nociception
A passive avoidance procedure was used to measure the ability to learn and remember to avoid a noxious stimulus in 13-month-old mice and to test the effects that treatment with cytidine(5')-diphosphocholine (CDP-choline) had on these processes. Half of the mice received 500 mg/kg per day CDP-choline orally for 4 months, and the two groups were compared with a third group of younger animals (4-month-old mice). The older mice showed marked impairment in the execution of these tests; however, those treated with CDP-choline had significant improvement in their performance 24 hours after learning the task.