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Alzheimer Lesions in the Entorhinal Region and Isocortex in Parkinson's and Alzheimer's Diseases a
Author(s) -
JELLINGER KURT,
BRAAK HEIKO,
BRAAK EVA,
FISCHER PETER
Publication year - 1991
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1991.tb00218.x
Subject(s) - entorhinal cortex , senile plaques , neuroscience , perforant pathway , hippocampus , alzheimer's disease , hippocampal formation , degenerative disease , dementia , neurofibrillary tangle , psychology , pathology , medicine , disease , central nervous system disease , perforant path , dentate gyrus
Neuropathologic examination in elderly individuals and patients with Parkinson's disease with and without dementia reveals abundant isocortical amyloid deposits with no or only a few neuritic plaques, neuropil threads (NT), and neurofibrillary tangles (NFT), whereas NT and NFT may be present only in the entorhinal region of the parahippocampal cortex. In Down's syndrome, Alzheimer's disease, and Parkinson's disease, early neuronal degeneration with deposition of NT and NFT may selectively involve layer pre-alpha (II) of the entorhinal region (Brodmann 26 area) forming the origin of the glutamatergic perforant pathway. Its bilateral destruction isolates the hippocampus from isocortical influx. Comparative studies in a series of aged subjects and those with Parkinson's disease show that psychostatus correlates better with the number of NT and NFT in the entorhinal region than in hippocampal area CA-1 and isocortex. This pattern of neuronal degeneration may explain cognitive impairment in early stages of both Alzheimer's and Parkinson's diseases.