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Recent Advances in the Neurochemical Pathology of Alzheimer's Disease
Author(s) -
NEMEROFF CHARLES B.,
BISSETTE GARTH,
SLOTKIN THEODORE A.,
SEIDLER FREDERIC J.,
MILLER BARNEY E.,
GHANBARI HOSSEIN
Publication year - 1991
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1991.tb00216.x
Subject(s) - neurochemical , cholinergic , somatostatin , alzheimer's disease , neuroscience , disease , postmortem studies , cholinergic neuron , medicine , pathology , degenerative disease , endocrinology , biology
Our findings from three postmortem tissue studies in Alzheimer's disease (AD) are presented. We investigated (1) alterations in somatostatin (SRIF) and corticotropin-releasing factor (CRF) in AD; (2) regulatory changes in presynaptic cholinergic function in AD; and (3) use of Alzheimer's disease-associated protein (ADAP) as a diagnostic test for AD in postmortem tissue. Taken together, these findings reveal marked reductions in SRIF and CRF concentrations in many cerebrocortical areas in AD, a marked up-regulation of cholinergic neuronal activity in surviving cholinergic neurons in AD, and excellent specificity and sensitivity for the use of the ADAP assay as a diagnostic test for AD in postmortem tissue.