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Physiologic Properties of Myelin Proteins Revealed by their Expression in Nonglial Cells
Author(s) -
COLMAN DAVID R.,
STAUGAITIS SUSAN M.,
D'URSO DONATELLA,
SINOWAY MICHELE P.,
ALLINQUANT BERNADETTE,
BERNIER LISE,
MENTABERRY ALEJANDRO,
STEMPAK JEROME G.,
BROPHY PETER J.
Publication year - 1990
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1990.tb42403.x
Subject(s) - columbia university , annals , medicine , physiology , pathology , anatomy , classics , history , sociology , media studies
The transfection paradigm described herein can be used to investigate the functional properties of individual nervous system proteins in ways that have not been explored before. In particular, observations on the "structural" proteins of myelin are being made that have already yielded certain unique insights into the physiologic properties of these polypeptides. The ease with which site-directed mutagenesis procedures can be applied to these systems should eventually enable us to define with great precision the "functional domains" within each myelin protein.