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Injection of Inactivated Phase I Coxiella burnetii Increases Non‐specific Resistance to Infection and Stimulates Lymphokine Production in Mice
Author(s) -
WAAG D. M.,
KENDE M.,
DAMROW T. A.,
WOOD O. L.,
WILLIAMS J. C.
Publication year - 1990
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1990.tb42221.x
Subject(s) - bacteriology , medicine , biology , bacteria , genetics
The encounter of phase I C. burnetii with the host results in seemingly disparate consequences. On the one hand, in vitro lymphocyte responses to mitogens and homologous recall antigen are suppressed. On the other, host resistance to a variety of infectious agents and to a tumor is increased. An explanation for this augmented immune response surely involves the ability of C. burnetii to stimulate cytokines, such as interferon and TNF, which enhance host immune function.