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Carcinoma of the Prostate. Guidelines for Treatment: The Role of Antiandrogens a
Author(s) -
PavoneMacaluso M.,
Cacciatore M.,
Daricello G.,
Pavone C.,
Serretta V.
Publication year - 1990
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1990.tb34306.x
Subject(s) - antiandrogens , flutamide , libido , medicine , prostate , potency , prostate cancer , elevated transaminases , oncology , carcinoma , transaminase , hormone , cancer , antiandrogen , gynecology , chemistry , enzyme , biochemistry , androgen receptor , in vitro
Our preliminary experience shows that flutamide is effective in patients with stage C or D prostate cancer. Local and distant response rates are comparable to those obtained with "classic" hormone therapy. Libido and sexual potency generally are unaffected. Palliation of symptoms, which is frequent, is usually accompanied by improved performance status and quality of life. Side effects are slight or moderate, but elevated transaminase levels in patients with borderline liver insufficiency are possible.