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Mechanisms of Matrix Degradation in Rheumatoid Arthritis a
Author(s) -
KRANE STEPHEN M.,
CONCA WALTER,
STEPHENSON MARY L.,
AMENTO EDWARD P.,
GOLDRIN MARY B.
Publication year - 1990
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1990.tb17943.x
Subject(s) - collagenase , extracellular matrix , microbiology and biotechnology , mesenchymal stem cell , chemistry , secretion , extracellular , receptor , cytokine , rheumatoid arthritis , matrix (chemical analysis) , biophysics , enzyme , biochemistry , biology , immunology , chromatography
In the inflammatory synovium production of collagenase is probably responsible for the degradation of collagen in the extracellular matrix and distortion of the architecture and function of the joints. Major collagenase-producing cells are mesenchymal cells such as fibroblasts and chondrocytes, which synthesize and secrete the enzyme influenced by the action of cytokines produced by adjacent mononuclear cells. The cytokines act primarily through cell-surface receptors, whose signal is probably then mediated by complexes of nuclear oncoproteins, to activate transcription of the procollagenase gene. The increased production of collagenase ultimately is the result of a cascade of cellular effects involving complex interactions of different ligands in a system characterized by amplification and feedback loops.