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Serotonin in Obsessions, Compulsions, and the Control of Aggressive Impulses
Author(s) -
INSEL THOMAS R.,
ZOHAR JOSEPH,
BENKELFAT CHAWKI,
MURPHY DENNIS L.
Publication year - 1990
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1990.tb16911.x
Subject(s) - mental health , annals , health science , psychology , library science , psychiatry , medicine , gerontology , history , classics , medical education , computer science
Serotonin has been implicated in a number of psychiatric syndromes, but it is obsessive-compulsive disorder (OCD) which currently provides the most compelling evidence of a link between serotonin and psychopathology. The precise nature of this link remains unclear-in spite of strong evidence implicating serotonin in the treatment of OCD, we still lack a clear model of serotonergic dysfunction to explain the pathophysiology of this syndrome. This paper will review the current literature regarding serotonin and OCD with a perspective relating serotonin not only to this syndrome but to disorders of impulse control. To this end, we will review clinical studies implicating serotonin in the modulation of aggressive and impulsive behavior.