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Precocious Expression of NAPA‐73, an Intermediate Filament‐Associated Protein, during Nervous System and Heart Development in the Chicken Embryo
Author(s) -
CIMENT GARY
Publication year - 1990
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1990.tb13213.x
Subject(s) - napa , neural crest , nervous system , intermediate filament , embryo , monoclonal antibody , biology , microbiology and biotechnology , epitope , protein filament , heart development , ultrastructure , antibody , anatomy , cell , neuroscience , cytoskeleton , genetics , gene , embryonic stem cell
A monoclonal antibody was generated, against early neural crest-derived cells, which recognizes an epitope present on a novel intermediate filament-associated protein. This protein has been named NAPA-73 and is expressed by progenitor cells of the nervous system and heart. Biochemical and ultrastructural studies indicate that this protein associates with bundles of intermediate filaments and therefore may play a role in the determination of cell shape.