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Feeding‐Associated Alterations in Striatal Neurotransmitter Release
Author(s) -
ACWORTH IAN N.,
RESSLER KERRY,
WURTMAN RICHARD J.
Publication year - 1989
Publication title -
annals of the new york academy of sciences
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1989.tb53307.x
Subject(s) - microdialysis , nucleus accumbens , dopaminergic , dopamine , neurotransmitter , extracellular fluid , extracellular , medicine , chemistry , endocrinology , striatum , glutamate receptor , homovanillic acid , central nervous system , biology , biochemistry , serotonin , receptor
Published evidence suggests a role for dopaminergic (DA) brain pathways in feeding-associated behaviors. Using the novel technique of brain microdialysis of striatal extracellular fluid (ECF) as an index of DA release, Church et al. described increases in levels of DA when animals had limited access to pellets, but not with free access. Dopamine release from the nucleus accumbens did increase with free access to pellets post starvation or after food reward. We used permanently implanted microdialysis probes to measure ECF levels of DA, DOPAC, HVA, and large neutral amino acids (LNAA) for up to 72 hours after implantation among rats experiencing different dietary regimens.