Premium
Regulation of CA II and H + , K + ‐ATPase Gene Expression in Canine Gastric Parietal Cells
Author(s) -
CAMPBELL VIRGINIA W.,
YAMADA TADATAKA
Publication year - 1989
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1989.tb25154.x
Subject(s) - annals , medicine , classics , history
Acid secretagogue-specific receptor activation in parietal cells triggers rapid and coordinate gene expression of gastric H+,K(+)-ATPase and of CA II. The rapid rise in steady-state levels of CA II mRNA is due to new transcription of the CA II gene in stimulated cells. Although the presumed function of CA II in activated parietal cells is to catalyze the generation of HCO3- from OH-, regulation of CA II gene expression appears to be independent of the generation of H+ (and OH-) through the action of H+,K(+)-ATPase.