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Transfusional Iron Overload in Sickle Cell Anemia
Author(s) -
SARNAIK SHARADA A.,
CHANG CHUNGHO,
HERNANDEZ RAMIRO
Publication year - 1989
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1989.tb24225.x
Subject(s) - boulevard , medicine , state hospital , university hospital , sickle cell anemia , general hospital , columbia university , family medicine , pediatrics , gerontology , sociology , psychiatry , history , media studies , disease , archaeology
Multiple exposures to blood transfusions can result in significant hepatic toxicity from viral infections and iron overload.’ This toxicity is cumulative and can be the limiting factor in an otherwise successful prophylactic transfusion regimen for specific complications of sickle cell disease which are both recurrent and life-threatening. This study was undertaken to determine the extent of hepatotoxicity in such patients and the value of magnetic resonance imaging (MRI) in its evaluation.