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Lipid Alterations and Cellular Properties of Sickle Red Cells a
Author(s) -
LUBIN BERTRAM,
KUYPERS FRANS,
CHIU DANIEL
Publication year - 1989
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1989.tb24154.x
Subject(s) - chemistry , biophysics , biology
Taken together, our studies and those in other laboratories demonstrate a number of membrane lipid changes in sickle erythrocytes. These include (1) changes in membrane phospholipid dynamics, (2) perturbation of the translocase protein that translocates aminophospholipids from the exterior leaflet to the interior leaflet, (3) perturbation of the interaction between membrane phospholipids and skeletal proteins, and (4) abnormal phospholipid molecular species compositions. The mechanism underlying these alterations may involve several independent effects. Included in these will be the oxidative damage that occurs to these membranes and the dissociation of lipids and proteins that accompanies the sickling process.