Premium
N ‐Ac‐Leukotriene E 4 Unique Vascular Activity in the Conscious Rat
Author(s) -
FEUERSTEIN G.,
LETTS G.,
SIREN AL.
Publication year - 1988
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1988.tb38573.x
Subject(s) - siren (mythology) , citation , library science , health science , medicine , annals , art , medical education , computer science , classics
N-Acetyl-leukotriene E, (N-Ac-LTE,) is a recently discovered metabolite of the cysteinyl leukotrienes (LT).' Although N-Ac-LTE, has been identified so far only in the bile, an enterohepatic cycle for LT has been suggested2 that might provide for some L T metabolites access to the systemic circulation. The biological significance of N-Ac-LTE, is not known. Experiments conducted in the pig show that N-Ac-LTE, has very weak actions on the cardiovascular and respiratory system^.^ However, the formation of N-Ac-LTE, has not been shown as yet in the pig. Therefore, we have decided to examine the effect of N-Ac-LTE, in the rat, where LTC,/D,/E, have potent cardiovascular effects and N-Ac-LTE, is a primary metabolite of the LT. Rats were anesthetized with ketamine-acepromazine. Next, a Doppler flow probe was implanted on the renal (R), mesenteric (M), and abdominal aorta (for hindquarter blood flow, HQ), and a PE-50 catheter was placed in the femoral artery for blood pressure (BP) monitoring. N-Ac-LTE, (Merck Frosst) was administered to the