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The Effects of a Novel Series of Selective Inhibitors of Arachidonate 5‐Lipoxygenase on Anaphylactic and Inflammatory Responses
Author(s) -
BHATTACHERJEE P.,
BOUGHTONSMITH N. K.,
FOLLENFANT R. L.,
GARLAND L. G.,
HIGGS G. A.,
HODSON H. F.,
ISLIP P. J.,
JACKSON W. P.,
MONCADA S.,
PAYNE A. N.,
RANDALL R. W.,
REYNOLDS C. H.,
SALMON J. A.,
TATESON J. E.,
WHITTLE B. J. R.
Publication year - 1988
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1988.tb38554.x
Subject(s) - obituary , philosophy , theology
In conclusion, we have described a novel series of acetohydroxamic acids that are potent and selective inhibitors of arachidonate 5-lipoxygenase in vitro and in vivo. In addition, we have shown that these compounds attenuate "leukotriene-dependent" anaphylactic bronchospasm, the accumulation of inflammatory leukocytes, and the development of fever in experimental models. It now remains to be determined if these compounds have any therapeutic value in man.