Premium
Long‐Term Carcinogenicity Bioassays on Three Chlorofluorocarbons (Trichlorofluoromethane, FC11; Dichlorodifluoromethane, FC12; Chlorodifluoromethane, FC22) Administered by Inhalation to Sprague‐Dawley Rats and Swiss Mice
Author(s) -
MALTONI CESARE,
LEFEMINE GIUSEPPE,
TOVOLI DANIELE,
PERINO GIORGIO
Publication year - 1988
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1988.tb30116.x
Subject(s) - library science , medicine , clinical oncology , computer science , cancer
Three propellant chlorofluorocarbons, namely trichlorofluoromethane (FC11), dichlorodifluoromethane (FC12), and chlorodifluoromethane (FC22) were administered by inhalation at a concentration of 5000, 1000 and 0 ppm, 4 hours daily, 5 days weekly, for 104 and 78 weeks, to rats and mice, respectively. The animals were kept under observation until spontaneous death. Under the experimental conditions, all three compounds failed to show any carcinogenic effects.