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Long‐Term Carcinogenicity Bioassay on Vinylidene Chloride Administered by Inhalation to Sprague‐Dawley Rats a
Author(s) -
COTTI GIULIANO,
MALTONI CESARE,
LEFEMINE GIUSEPPE
Publication year - 1988
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1988.tb30109.x
Subject(s) - library science , international agency , medicine , oncology , cancer , computer science
Vinylidene chloride was administered by inhalation, 7 hours daily, 5 days weekly, at the concentration of 100 and 0 ppm, to Sprague-Dawley rats. The treatment was started on 13-week-old breeders, and male and female offspring (12-day embryos). The breeders and some of the offspring were exposed for 104 weeks; the other offspring were exposed for 15 weeks only. An increased incidence was found of malignant tumors and of leukemias, particularly in offspring treated for 104 weeks.