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Where Do Different Neurons Come From?
Author(s) -
McKAY RON
Publication year - 1988
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1988.tb27050.x
Subject(s) - neuroscience , cell culture , biology , function (biology) , transplantation , precursor cell , gene , central nervous system , diversity (politics) , nervous system , cell , computational biology , microbiology and biotechnology , genetics , medicine , sociology , surgery , anthropology
SUMMARY The ability to make functionally competent brain precursor cell lines may have important consequences for a number of outstanding questions in mammalian CNS development. The diversity of neurons is one of the most striking conclusions of recent molecular studies of the nervous system. In our work we provided some of the earliest data to support this conclusion. 30‐32 Our preliminary data with precursor cell lines suggest that these cells give neurons with highly differentiated characteristics. If further work continues to support this conclusion, then immortal cell lines will be useful in analyzing the mechanisms that make neurons different. The methods that can be applied to these cell lines include manipulation in tissue culture, transplantation into the developing CNS, and application of the methods of mammalian cell genetics to link gene function to neuronal specificity.