Premium
Vasoactive Intestinal Peptide Receptors in Human Platelet Membrane. Characterization of Binding and Functional Activity
Author(s) -
ERCAL N.,
O'DORISIO M. S.,
VINIK A.,
O'DORISIO T. M.,
KADROFSKE M.
Publication year - 1988
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1988.tb27036.x
Subject(s) - medicine , physiology , gerontology
Vasoactive intestinal peptide (VIP) mediated inhibition of platelet aggregation has been demonstrated in rabbit platelets.’ While the mechanism by which VIP inhibits aggregation is thought to be via a specific receptor linked to adenylate cyclase, platelet receptors for VIP have not yet been demonstrated. The current studies were designed to test whether VIP regulates aggregation in human platelets and to determine whether specific, high-affinity VIP receptors are expressed on platelet membranes.