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Interleukin‐1 Alpha mRNA Induced by Cycloheximide, PMA, and Retinoic Acid Is Reduced by Dexamethasone in PAM‐212 Keratinocytes
Author(s) -
MCGUIRE JSEPH,
LANGDON ROBERT,
BIRCHALL NICHOLAS,
KUPPER THOMAS
Publication year - 1988
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1988.tb18816.x
Subject(s) - haven , medicine , gerontology , mathematics , combinatorics
Keratinocytes in culture produce detectable amounts of IL-1 alpha mRNA constitutively and can be stimulated to express increased amounts of IL-1 alpha mRNA by cycloheximide, PMA, and retinoic acid. Dexamethasone decreases the amount of IL-1 mRNA induced by these agents, as well as constitutive IL-1 alpha mRNA. RU 486, which interferes with glucocorticosteroid-receptor binding, decreases inhibition of TPA stimulation of IL-1 alpha mRNA by dexamethasone, which suggests that the inhibition by dexamethasone is through a conventional ligand-receptor mechanism.