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T‐Lymphocyte Subpopulation Levels and Immunoglobulin Changes in the Cerebrospinal Fluid of Patients with Neurologic Disorders
Author(s) -
PIRTTILÄ T.,
ANTONEN J.,
SYRJÄLÄ P.,
FREY H.
Publication year - 1987
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1987.tb35831.x
Subject(s) - cerebrospinal fluid , multiple sclerosis , immunology , pathogenesis , antibody , lymphocyte , medicine , t lymphocyte , pathology , immune system
Immunologic mechanisms are thought to play an important role in the pathogenesis of multiple sclerosis (MS). In this study we examined cerebrospinal fluid (CSF) samples of 29 patients with MS and of 24 patients with other neurological disorders. An elevated T-helper (Th)/T-suppressor (Ts) ratio was typical for the CSF of patients with MS. There was a clear positive correlation between the percentage of Th cells and the existence of oligoclonal bands in the CSF. On the other hand, the percentage of Ts cells correlated negatively with the existence of oligoclonal bands in the CSF. The imbalance of CSF T-lymphocyte subpopulations may be one of the fundamental defects in MS, and the observed alterations in CSF immunoglobulin synthesis pattern might only reflect these changes.