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Gonadal Development and Gametogenesis in the Hypogonadal Mouse Are Restored by Gene Transfer
Author(s) -
MASON ANTHONY J.,
PITTS SHARON L.,
NIKOLICS KAROLY,
SZONYI EVA,
WILCOX JOSIAH N.,
SEEBURG PETER H.,
STEWART TIMOTHY A.
Publication year - 1987
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1987.tb24995.x
Subject(s) - biology , library science , computer science
These results describe controlled regulation of a mammalian neural gene in transgenic mice. Analysis of truncated GnRH-GAP genes in transgenic mice will enable us to define the DNA sequences responsible for this control. Furthermore, by separate mutation of the GnRH and GAP coding sequences we will be able to determine the relative importance of these two peptides in the development and maintenance of reproductive function.