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Evidence against Linkage of von Recklinghausen Neurofibromatosis and Chromosome 19 Markers
Author(s) -
HUSON S. M.,
MEREDITH A. L.,
SARFARAZI M.,
SHAW D. J.,
BROOK D.,
COMPSTON D. A. S.,
HARPER P. S.
Publication year - 1986
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1986.tb48088.x
Subject(s) - medical genetics , section (typography) , medicine , family medicine , gerontology , library science , genetics , biology , gene , advertising , computer science , business
In this paper we report the study of the segregation of three chromosome 19 markers known to be linked to myotonic dystrophy in nine families with von Recklinghausen neurofibromatosis. Clear evidence against linkage was found for all three markers excluding the von Recklinghausen neurofibromatosis gene from the myotonic dystrophy region of chromosome 19.