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Monoclonal Antibody Studies Defining the Origin and Properties of Autoantibodies in Graves' Disease
Author(s) -
KOHN LEONARD D.,
ALVAREZ FRANCISCO,
MARCOCCI CLAUDIO,
KOHN ANDREA D.,
CORDA DANIELA,
HOFFMAN WILLIAM E.,
TOMBACCINI DONATELLA,
VALENTE WILLIAM A.,
DE LUCA MICHELE,
SANTISTEBAN PILAR,
GROLLMAN EVELYN F.
Publication year - 1986
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1986.tb20865.x
Subject(s) - autoantibody , thyroglobulin , monoclonal antibody , receptor , anti thyroid autoantibodies , thyroid , thyrotropin receptor , autoimmune disease , immunology , pathogenesis , antibody , disease , medicine , endocrinology
The present report summarizes experiments with monoclonal antibodies to the TSH receptor. The data provide further insight into the TSH receptor structure and into the basis of autoimmune antibodies implicated in the pathogenesis of Graves' disease. They resolve many clinical questions and provide new approaches to enhance our understanding of autoimmune disease. In one new approach, it has been noted that the 11E8 TBIAb can precipitate the phosphorylated beta subunit of the insulin and IGF1 receptor. This cross-reactivity or recognition of determinants adjacent to the TSH receptor may not be random. Insulin, IGF1, alpha 1 adrenergic, and TSH receptors have been linked to a synergistic cascade response system of the thyroid involving growth, thyroglobulin biosynthesis, iodination of thyroglobulin, and thyroid hormone formation. Future studies with the monoclonals may help unravel this cascade system and its regulatory relationships, along with the relationships between autoimmune thyroid disease and autoimmune diseases of other organs.