Premium
Spontaneous Production of Interleukin‐2 in the Supernatants of Cultured Cutaneous Sarcoidal Granulomas
Author(s) -
KATARIA Y. P.,
PADGETT R. C.,
ENGLISH L. S.
Publication year - 1986
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1986.tb18491.x
Subject(s) - chapel , reprint , medicine , general pathology , library science , citation , history , classics , pathology , art history , computer science , physics , astronomy
Biopsies of cutaneous sarcoidal lesions were cultured for 24 hr in vitro, and the cell-free supernatants were examined for the presence of T cell growth factor (IL-2). Low levels of IL-2 were detected in these supernatants based on their ability to support the growth of cultured T cells. The apparent molecular mass of the active component in these supernatants, as assessed by exclusion chromatography, was 14,900 daltons. These findings suggest that IL-2 production within these sarcoidal lesions may be partly responsible for their evolution and maintenance.