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Role of Alveolar Macrophage‐ and Lung T Cell‐derived Mediators in Pulmonary Sarcoidosis
Author(s) -
HUNNINGHAKE GARY W.
Publication year - 1986
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1986.tb18483.x
Subject(s) - alveolar macrophage , sarcoidosis , pulmonary sarcoidosis , macrophage , lung , medicine , pathology , immunology , chemistry , biochemistry , in vitro
The process of granuloma formation in the lung is mediated by an intimate interaction between macrophages and T cells, and this interaction provides the appropriate environment for granuloma formation and the development of fibrosis. Much of this process of granuloma formation and fibrosis appears to be triggered by the release of immune mediators by alveolar macrophages and lung T cells.