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Biochemistry of Sodium Channels from Mammalian Muscle
Author(s) -
BARCHI ROBERT L.
Publication year - 1986
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1986.tb15569.x
Subject(s) - annals , citation , library science , philosophy , medicine , classics , art , computer science
Sodium channels from rat and rabbit skeletal muscle have been isolated, characterized, and functionally reconstituted. These channel proteins closely resemble those purified from the eel electroplax and from rat brain. Work now in progress on the determination of the primary sequence of the 260 kDa subunit through the cloning and sequencing of the muscle message should shed further light on the relationship between these unique voltage-sensitive sodium channels.