Premium
Isolation and Characterization of the Human Fibrillar Collagen Genes a
Author(s) -
RAMIREZ FRANCESCO,
BERNARD MICHAEL,
CHU MONLI,
DICKSON LEON,
SANGIORGI FRANK,
WEIL DOMINIQUE,
WET WOUTER,
JUNIEN CLAUDINE,
SOBEL MARK
Publication year - 1985
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1985.tb51160.x
Subject(s) - intron , gene , exon , biology , genetics , complementary dna
In order to elucidate some of the mechanisms leading to the pathological expression of the human fibrillar collagens, as well as to understand the evolution of these loci, specific cDNA and genomic clones have been isolated. The primary structure of the COOH-terminal propeptide of the four collagen chains and either part or the entire exon/intron arrangement of the genes have been determined. Interspecies and pairwise comparison revealed that the four loci have evolved at slightly different rates, maintaining, however, remarkably similar exon/intron arrangement. The fibrillar genes, albeit sharing the same elaborate structure, exhibit different sizes that correlate with the average length of their intron sequences, possibly because of their different chromosomal origin.