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Cholecystokinin and Gastrin Forms in the Nervous System
Author(s) -
DOCKRAY G. J.,
DESMOND H.,
GAYTON R. J.,
JONSSON AC.,
RAYBOULD H.,
SHARKEY K. A.,
VARRO A.,
WILLIAMS R. G.
Publication year - 1985
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1985.tb29904.x
Subject(s) - gastrin , cholecystokinin , nervous system , gastrointestinal hormone , neuroscience , endocrinology , chemistry , medicine , biology , neuropeptide , receptor , secretion
Cholecystokinin octapeptide is the predominant representative of the gastrin-CCK family in the central nervous system. Other forms occur in low concentrations, or restricted locations, as do the gastrins. The pathways of biosynthetic processing can now be studied in detail, following the elucidation of the cDNA sequence for the two peptides. In the vagus both CCK and gastrin can be found. Brain stem neurons receiving an input from gastric mechanoreceptors respond to CCK-8, but most do not respond to gastrin given intravenously or intra-arterially. This system, which may well be involved in mediating the peripheral satiety effect of CCK, is therefore able to distinguish between the two peptides.