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Redifferentiation of Cancer Cells: Bestatin, Estradiol, and Prostaglandin D 2
Author(s) -
OKUYAMA SHINICHI,
MISHINA HITOSHI,
MAKI TETSUO
Publication year - 1985
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1985.tb20838.x
Subject(s) - medicine , honor , citation , pediatrics , library science , computer science , operating system
The induction of redifferentiation of cancer cells was studied. This was achievable with bestatin, especially in combination with sex hormones or prostaglandin D2, in murine undifferentiated mammary adenocarcinoma cells in vitro. Prostaglandin D2 also exerted a similar redifferentiating effect on M1 murine leukemia cells and a consecutive bestatin-hormone regimen was effective in endocrine tumors in man. Cancer redifferentiation may one day be developed into a clinical technique.