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Cell Kinetic Studies of the Effect of Cytotoxic Drugs on Survival and Proliferation of Ascites and Solid Tumor Cells of the Mouse
Author(s) -
SCHULTZE B.,
FIETKAU R.,
SCHÄFER E.,
BASSUKAS I.
Publication year - 1985
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1985.tb20837.x
Subject(s) - cytotoxic t cell , ascites , tumor cells , drug , cancer research , solid tumor , chemotherapy , cytotoxicity , neoplasm , chemistry , biology , pharmacology , immunology , medicine , pathology , cancer , in vitro , biochemistry
The three studies discussed show that the response of experimental ascites and solid tumors, as well as of the host organism, to a cytotoxic drug can be studied quantitatively with cell kinetic methods. Knowledge of this kind is necessary in the attempt to improve the application of cytotoxic drugs in chemotherapy of tumors which up to now has been based mainly on pure empiricism.