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IMMUNOLOGIC STUDIES OF THE ACQUIRED IMMUNE DEFICIENCY SYNDROME: RELATIONSHIP OF IMMUNODEFICIENCY TO EXTENT OF DISEASE a
Author(s) -
Hersh Evan M.,
Reuben James M.,
Mansell Peter W. A.,
Rios Adan,
Gutterman Jordan U.,
Munn Gwyneth,
Murray J. Lee,
Spector Steven P.,
Goldstein Allan L.,
Newell Guy R.
Publication year - 1984
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1984.tb37156.x
Subject(s) - immune system , immunology , immunodeficiency , disease , medicine , lymphocyte , thymosin , monocyte , 5' nucleotidase , immunopathology , adenosine
Immunologic and conventional laboratory studies were done in 135 previously untreated subjects including 28 (20.7%) symptom-free homosexuals and 74 (54.8%) with ARC and 33 (24.5%) with AIDS. More than half of all patients had abnormal percentages of lymphocytes, percentages of T3+ cells, percentage and absolute number of T4+ cells, percentage of T8+ cells, T4/T8 ratio, monocyte adherence, and serum thymosin alpha 1. Most immune variables worsened with progressive disease. Low lymphocyte 5'nucleotidase increased suppressor cell activity, and impaired IL-2 and alpha interferon production and response suggest diminished mature and increased immature peripheral blood and tissue T cells. These findings suggest approaches to staging, prognostication, and treatment for AIDS.