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NCA: A DIFFERENTIATION ANTIGEN OF MYELOPOIETIC CELLS IN HUMANS AND HOMINOID MONKEYS
Author(s) -
Wahren Britta,
Gadler Fredrik,
Gahrton Gösta,
Hammarström Sten,
Hareland Yngve,
Hydén Nils,
Ljungdahl Ewa,
Måhlén Anders,
Rudén Ulla,
Wiklund Mane
Publication year - 1983
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1983.tb32877.x
Subject(s) - antigen , immunology , biology , microbiology and biotechnology
NCA, a normal colonic and granulocytic antigen, could be demonstrated in serum and in myelopoietic, but not lymphopoietic or erythropoietic, cells of Homo sapiens and other Primates. The levels of NCA in both serum and myelopoietic cells of Homo and hominoids were higher than those of more distant relatives of the same order. Thus, the classic phylogenetic differences are reflected also by the distribution of NCA. Hyperimmunization of Macaca irus, in which the NCA content of serum and cells is low, led to occurrence of anti-NCA IgG in all animals. The phylogenetic differences may accordingly have to do with slight antigenic NCA differences between Homo and other Primates rather than differences in amount only. Purified NCA did not affect growth and maturation of myelopoietic stem cells in vitro, whereas anti-NCA inhibited development of the majority of myelopoietic clusters and colonies.