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RADIOIMMUNODETECTION OF CANCER USING ANTIBODIES TO α‐FETOPROTEIN AND CARCINOEMBRYONIC ANTIGEN
Author(s) -
Ishii Nobuko,
Nakata Keisuke,
Muro Toyokichi,
Furukawa Ryuji,
Kono Kenji,
Kusumoto Yukio,
Munehisa Tatsuo,
Koji Toshihiko,
Nagataki Shigenobu,
Nishi Shinzo,
Tsukada Yutaka,
Hirai Hidematsu
Publication year - 1983
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1983.tb32870.x
Subject(s) - immunoscintigraphy , carcinoembryonic antigen , antibody , monoclonal antibody , polyclonal antibodies , medicine , antigen , radioimmunoassay , cancer , pathology , immunology , radioimmunotherapy
This study reports the use of radiolabeled antibody to AFP and CEA for the detection and localization of AFP- or CEA-producing tumors. Thirty-one patients received 131I-labeled anti-AFP or anti-CEA antibodies. Photoscans were taken at 24 and 48 hours after injection of radioantibodies. In three of six patients with CEA-producing tumors, radioimmunodetection with anti-CEA antibody showed positive scans. In AFP-producing tumors, 7 of 15 patients had positive findings on immunoscintigraphy using polyclonal anti-AFP antibody, and two of nine patients had positive findings when monoclonal antibodies were used. Analysis of radioantibody in the blood after injection showed both complex and free antibody with immunoreactivity in the circulation, and smaller complexes were seen to form after administration of monoclonal antibodies.