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THE ROLE OF NONESTERIFLED FATTY ACIDS AND OF α 1 ‐FETOPROTEIN IN ESTROGEN‐DEPENDENT ENDOCRINE SYSTEMS
Author(s) -
Nunez E. A.,
Benassayag C.,
Vallette G.,
Savu L.,
ClercHofmann F.,
Delorme J.,
Christeff N.
Publication year - 1983
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1983.tb32858.x
Subject(s) - humanities , library science , political science , medicine , art , computer science
We discuss the various experimental findings to date that indicate that AFP may be considered as a positive or negative modulator of estrogenic action. Moreover, we show that this protein, even when nonestrogenophilic, is able to bind other hydrophobic ligands, in particular nonesterified fatty acids. These fatty acids inhibit the binding of estrogens to murine AFP as well as to the cytosolic estrogen receptors. Thus, the AFPs of all species--whether or not estrogenophilic--might play an endocrinologic role through the intermediary of the unsaturated fatty acids to which they associate with high affinity.