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THE IgA RESPONSE: INDUCTIVE ASPECTS, REGULATORY CELLS, AND EFFECTOR FUNCTIONS *
Author(s) -
Michalek Suzanne M.,
McGhee Jerry R.,
Kiyono Hiroshi,
Colwell Dawn E.,
Eldridge John H.,
Wannemuehler Michael J.,
Koopman William J.
Publication year - 1983
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1983.tb26859.x
Subject(s) - immune system , immunology , biology , antigen , effector , isotype , homeostasis , b cell , regulatory b cells , microbiology and biotechnology , antibody , interleukin 10 , monoclonal antibody
In this review, we have emphasized our current studies on the inductive aspects of the IgA immune response and homeostatic mechanisms involved in the induction of oral tolerance. By use of unique inbred mouse strains in restricted microbial environments, we have provided evidence for a central role of LPS in systemic unresponsiveness to orally encountered antigens. We have continued studies on characterization of GALT lymphoreticular cell types, including accessory cells, regulatory T-cells, and precursor IgA B-cells. We have placed recent emphasis on characterization of antigen-specific Th-cell clones derived from murine PP, which preferentially support IgA isotype responses. Relevant areas for continued research have been emphasized in this review.