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THE FIBRINOGEN‐DEPENDENT PATHWAY OF PLATELET AGGREGATION *
Author(s) -
Marguerie Gerard A.,
Plow Edward F.
Publication year - 1983
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1983.tb23272.x
Subject(s) - fibrinogen , platelet , platelet aggregation , chemistry , receptor , biophysics , microbiology and biotechnology , biochemistry , immunology , biology
Fibrinogen participates in platelet aggregation induced by ADP and this participation is receptor mediated. The role of fibrinogen in platelet function is not restricted to the ADP stimulus as the molecule may regulate aggregation induced by the direct interaction of the protein with a single, specific receptor system. Thus, a common fibrinogen-dependent mechanism leading to platelet aggregation is hypothesized.