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TRANSLATIONAL AND COTRANSLATIONAL EVENTS IN FIBRINOGEN SYNTHESIS *
Author(s) -
Fuller Gerald M.,
Nickerson John M.,
Adams Mark A.
Publication year - 1983
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1983.tb23264.x
Subject(s) - fibrinogen , hepatocyte , computational biology , protein biosynthesis , microbiology and biotechnology , chemistry , biology , computer science , biochemistry , in vitro
What we have shown in these studies are some of the first steps in the assembly of fibrinogen. We believe that using the hepatocyte culture system together with molecules capable of stimulating an increase in synthesis holds much promise in helping to learn how the cell puts together this elegant and complicated molecule. Moreover, these studies may also provide clues to mechanisms operant for other complex proteins produced by the liver.