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A POSSIBLE MECHANISM OF IMMUNOREGULATION PRODUCED BY α 2 ‐MACROGLOBULIN
Author(s) -
Alomran A.,
Shenton B. K.,
Donnelly P. K.,
Francis D. M. A.,
Proud G.,
Taylor R. M. R.
Publication year - 1983
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1983.tb18131.x
Subject(s) - proteases , peptide , lymphocyte , alpha 2 macroglobulin , pancreatitis , chemistry , alpha (finance) , medicine , immunology , macroglobulin , endocrinology , biochemistry , biology , enzyme , construct validity , nursing , patient satisfaction
Most of the plasma suppressive activity was associated with alpha 2M in both normal subjects and cancer patients. alpha 2M binding to physiological levels of proteases was associated with an increase in the ability to suppress lymphocyte reactivity in the TEEM test. alpha 2M binding to proteases released a peptide that was a component of the alpha 2M; this peptide suppressed lymphocyte reactivity to mitogenic, antigenic, and allogenic stimuli in the TEEM test and in the lymphocyte transformation assay. Physically and biologically similar peptides have been found in the plasma of cancer patients and patients with thermal burns, uremia, and acute pancreatitis.