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A PROBE OF THE HUMAN PLASMIN‐α 2 ‐MACROGLOBULIN INTERACTION UTILIZING MONOCLONAL ANTIBODIES TO HUMAN PLASMIN a
Author(s) -
Cummings Helen S.,
Castellino Francis J.
Publication year - 1983
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1983.tb18101.x
Subject(s) - citation , library science , plasmin , chemistry , computer science , biochemistry , enzyme
These experiments have shown that alpha 2M may have a bait region capable of accommodating proteases of a far greater molecular weight than previously recognized, since antibody-plasmin complexes apparently become entrapped. In the case of large proteases, however, it now appears that a portion of these molecules is not enclosed. Clearly, in the case of plasmin, the K1-4 region remains outside the molecular trap.