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EXAGGERATED NATRIURETIC RESPONSE OF BRATTLEBORO RATS TO EXTRACELLULAR VOLUME EXPANSION
Author(s) -
OpavaStitzer S.,
FernándezRepollet E.,
RodriguezSargent C.,
Cangiano J. L.,
MartínezMaldonado M.
Publication year - 1982
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1982.tb37430.x
Subject(s) - extracellular fluid , extracellular , volume (thermodynamics) , medicine , endocrinology , plasma volume , chemistry , physics , biochemistry , thermodynamics
A state of chronic dehydration with reduced plasma volume,' decreased blood pressure,* and increased plasma renin activity (PRA) *-.I has been demonstrated in rats with hereditary hypothalamic diabetes insipidus (DI rats). In this situation decreased renal perfusion and glomerular filtration rate might result in sodium retention. On the other hand, the DI rat also suffers from mineralocorticoid deficiency 6-8 which might result in salt wasting. In addition it has recently been shown that in contrast to normal rats, there are no differences between superficial cortical and juxtamedullary nephrons of the DI rat with respect to single nephron filtration rate, glomerular volume, and proximal tubular length.g This lack of internephron heterogeneity might also affect renal sodium handling in the DI rat. It thus seems of particular interest to evaluate the natriuretic response of DI rats to volume expansion. In the present study, the natriuretic responses of DI and normal Long-Evans rats to acute and chronic volume expansion were compared. Other factors involved in sodium handling, namely mineralocorticoids and renal (Na+ + K+) ATPase activity, were also studied.