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IN VIVO REGULATION OF THE PRIMARY RESPONSE OF CYTOLYTIC T CELLS TO HAPTEN‐ALTERED SELF ANTIGENS BY AN INDUCIBLE SUPPRESSOR T CELL *
Author(s) -
Battisto J. R.,
Wong H. L.
Publication year - 1982
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1982.tb36104.x
Subject(s) - cytolysis , suppressor , hapten , antigen , in vivo , microbiology and biotechnology , chemistry , immunology , biology , in vitro , cytotoxic t cell , biochemistry , genetics , gene
Tc directed toward hapten-altered self antigens have been prevented from appearing in vivo inducing tolerance with hapten-derivatized syngeneic spleen cells. When the latter cells were coinjected intravenously with hapten-tolerized spleen cells one week before attempting sensitization for Tc, the hapten-specific Tc were not generated. Tolerance induced in this manner was adoptively transferable to untreated hosts using spleen cells of tolerized animals. The cell responsible for down regulating the CML response was identified as a theta antigen-bearing cell. Three additional methods have been described in which induction of Tc could be prevented by tolerance initiated through the use of hapten-derivatized syngeneic spleen cells. Common to all four methods is a two-week interval between the initial administration of tolerogen and the start of sensitization for Tc formation.