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C‐REACTIVE PROTEIN REACTIVITY WITH COMPLEMENT AND EFFECTS ON PHAGOCYTOSIS *
Author(s) -
Mold Carolyn,
Du Clos Terry W.,
Nakayama Shuei,
Edwards Kathryn M.,
Gewurz Henry
Publication year - 1982
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1982.tb22141.x
Subject(s) - phagocytosis , complement (music) , chemistry , reactivity (psychology) , complement system , immunology , microbiology and biotechnology , biology , medicine , biochemistry , antibody , pathology , phenotype , alternative medicine , complementation , gene
In the studies described here we have attempted to evaluate the hypothesis that CRP may function in host defense using two systems in which CRP in the presence of C appears to have opsonic properties. In the first, CRP and C were found to stimulate ingestion of erythrocytes by human monocyte or mouse macrophages in vitro, and to alter clearance patterns in vivo. In the second, we have studied opsonization of S. pneumoniae by CRP and C. Experiments with human neutrophils indicate that although CRP and C can enhance opsonization of S. pneumoniae, this effect is more pronounced in the absence of antibody. In vivo CRP was found to protect mice against intravenous infection with S. pneumoniae.