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ESSENTIAL THROMBOCYTHEMIA WITH TRANSITION INTO ACUTE LEUKEMIA
Author(s) -
Raman Sundara B. K.,
Mahmood Ahmad,
Slyck Ellis J.,
Saeed Sheikh M.
Publication year - 1981
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1981.tb29729.x
Subject(s) - hematopathology , hematology , medicine , biology , biochemistry , cytogenetics , chromosome , gene
A 57-year-old black man with sustained platelet count of 2 million/mm3 and evidence of intermittent gastrointestinal bleeding was diagnosed as having essential thrombocythemia. Studies of bone marrow morphology, platelet aggregation, and other variables were confirmatory of the disease. The patient was treated briefly with low doses of Myleran for less than three weeks. He was then lost to follow-up study. Approximately 16 months later he reappeared complaining of recurrent nose bleeds. He was found to be pancytopenic and diagnosis of acute leukemia was made on the basis of bone marrow aspiration.