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SIGNAL SEQUENCES FOR EARLY EVENTS IN PROTEIN SECRETION AND MEMBRANE ASSEMBLY
Author(s) -
Lingappa Vishwanath R.,
Lingappa Jaisri R.,
Blobel Günter
Publication year - 1980
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1980.tb47264.x
Subject(s) - citation , library science , computer science
Signal sequences for the transfer of proteins across membranes are usually found at the NH2-terminus of nascent secretory and transmembrane proteins. The functionally equivalent signal sequence of chicken ovalbumin however, is localized in the middle of the molecule. The implication of this surprising finding for biogenesis of membrane proteins is discussed.