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ASPECTS OF PARIETAL CELL BIOLOGY: CELLS AND VESICLES *
Author(s) -
Sachs G.,
Berglindh T.,
Rabon E.,
Stewart H. B.,
Barcellona M. L.,
Wallmark B.,
Saccomani G.
Publication year - 1980
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1980.tb47181.x
Subject(s) - vesicle , parietal cell , microvillus , secretory vesicle , chemistry , biophysics , sequence (biology) , microbiology and biotechnology , biochemistry , biology , gastric mucosa , membrane , stomach
Many features of these gastric vesicles satisfy the requirements for the gastric H+ pump. For example, we have: (a) K+ requirement, (b) KA for K+ of about 30 mM; (c) identical cation sequence for tissue and vesicles, (d) similar anion sequence, (e) localization at the microvillus of the secretory canaliculus, (f) TI+ inhibiting H+ transport of both systems, and (g) the K+ gradient satisfying the osmotic gradient requirement for HCl-flow out of the parietal cell. Points that require explanation are lack of SCN- effects and regulation of KCl permeability.