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EVALUATION OF CARDIAC FUNCTION IN PATIENTS WITH THALASSEMIA MAJOR
Author(s) -
Nienhuis Arthur W.,
Griffith Patricia,
Strawczynski Hanna,
Henry Walter,
Borer Jeffrey,
Leon Martin,
Anderson W. French
Publication year - 1980
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1980.tb33677.x
Subject(s) - thalassemia , cardiac function curve , function (biology) , medicine , cardiology , biology , genetics , heart failure
The application of noninvasive techniques to the evaluation of cardiac function in iron overload has identified a high incidence of abnormalities in asymptomatic patients prior to the onset of overt cardiac deterioration. Of the tests we have used, radionuclide cineangiography appears to be the most sensitive because it can be conveniently applied during the physiological stress of exercise. Other tests of cardiac function that include stress are also likely to be more sensitive than resting measurements of cardiac function. Systematic application of these techniques to the study of patients on iron chelation therapy should results in an early determination of the efficacy of such treatment.