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PATHOPHYSIOLOGY OF THALASSEMIA
Author(s) -
Zaino Edward C.
Publication year - 1980
Publication title -
annals of the new york academy of sciences
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1980.tb33669.x
Subject(s) - hemosiderosis , thalassemia , pathophysiology , medicine , anemia , bone marrow , beta thalassemia , hemolytic anemia , pathology
The clinical manifestations in homozygous thalassemia may be attributed to the defect in hemoglobin synthesis (Figure 16). It is best typified by beta thalassemia, where excess alpha chains accumulate to form intracytoplasmic erythrocytic inclusions. This leads to anemia, bone marrow hyperplasia, osteoporosis, hemosiderosis, and organ failure.