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REGULATION OF GLOBIN GENE EXPRESSION AT THE MOLECULAR LEVEL
Author(s) -
Anderson W. French
Publication year - 1980
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1980.tb33667.x
Subject(s) - annals , citation , hematology , medicine , library science , gerontology , classics , history , computer science
(1) Globin gene regulatory factors, and the DNA sites on which they act, are being sought. (2) Positive and negative regulatory factors that influence globin gene expression have been identified. The positive factor(s) is globin gene specific. (3) Assays are being developed using cloned globin genes to (a) purify the positive globin regulatory factor(s) in a cell-free transcription assay, and (b) identify the DNA sites that act as control regions by microinjection of "full-length" and shortened genomic genes into MEL cells. (4) Globin genes from mouse and human thalassemia cells are being studied as models of abnormal globin gene expression.