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REGULATION OF PROLIFERATION OF NORMAL AND NEOPLASTIC RAT LIVER CELLS BY CALCIUM AND CYCLIC AMP
Author(s) -
Swierenga S. H. H.,
Whitfield J. F.,
Boynton A. L.,
MacManus J. P.,
Rixon R. H.,
Sikorska M.,
Tsang B. K.,
Walker P. R.
Publication year - 1980
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1980.tb29534.x
Subject(s) - dna synthesis , calcium , in vitro , carcinogen , chemistry , dna , microbiology and biotechnology , biochemistry , cancer research , medicine , endocrinology , biology , organic chemistry
Calcium and cyclic AMP control the proliferation of nontumorigenic liver cells. These agents seem to be cogenerators of a signal to start synthesizing deoxyribonucleotides, the earliest of the DNA synthetic processes. By contrast, calcium has little or no effect on the proliferation of tumorigenic cells in vitro. Some possible reasons for this loss of control are presented, and the usefulness of this property as a tool for the detection of carcinogens is discussed.